Oxnard Calif. March 25 2020 Exercise has been shown to have a cooling effect on blood vessels and to help prevent cardiovascular diseases. However many exercise-related diseases including cardiomyopathy present with preferential vascular adaptations leading to a reduction in oxygen delivery to the tissues. Intensive lifestyle exercise has been found to increase the beta cells of the heart which produce production of the hormone vasoactive intestinal peptide and endothelium-stimulating factor (VIF).
A new study from the University of California Irvines CardioLab Molecular Imaging Center revealed that blocking the activity of a key protein in the production of VIF reduces vascular adaptations and bivaches disease. The results of the study involving mice bearing human genetic material will be published in the journal Cell.
Cardiac arrhythmias cause rapid irregular heartbeat which may increase the length of time before a person is diagnosed with cardiac disease endangering their ability to effectively control blood pressure and blood glucose levels. Cardiomyopathy can present as early as four years of age presenting with progressive muscle weakness and increased left ventricle pressure. Symptoms include progressive aortic aneurysm aortic aortic aneurysm with aortic valve narrowing angina requiring immediate surgical action and large vessel obstruction. More than 2 million people worldwide are affected.
Current treatments for cardiac arrhythmias focus on medications to tense blood vessels. However the disease is also associated with chronic inflammation that underlie the development of cardiomyopathy with constant circulation reduction caused by what are known as traumatic remodeling that is inflammation from injury or disease.
Many studies have attempted to lessen the chronic inflammation that propels 90 percent of cases of cardiomyopathy but the first result was negative with little benefit. A second trial involving hundreds of patients demonstrated an improvement in cardiomyopathy symptoms but the researchers reported no clinically significant change among the patients.
The present study was designed to create the first randomized controlled trial to determine the efficacy and safety of exercise in reducing the onset and progression of cardiomyopathy.
Chronic-but not acute-exercise reductions inflammation and improved physiological adaptation.
Mice were randomly assigned to two groups: one group began an exercise program of three weeks consisting of 60 minutes of intensive-intensity aerobic exercise five days a week. The second group typically taking prescribed medications for mild to moderate acute inflammation began the same regimen.
After 30 days the mice in the exercise group were placed on either a high- or low- 60- or 90-minute high-intensity continuous moderate-intensity aerobic exercise training regimen. Both groups underwent mechanical and behavioral studies in vivo sagittal- and longitudinal arterial anteroposterior-to-subarietal pressure changes blood pressure kinetics and blood lactate and glucose concentrations. The mice in the high-intensity group ingested an aLCAM containing sodium calcium chloride and urentic acid while the mice in the low-intensity group ingested lactose and glucose.
The mice in the high- and low-intensity progressive groups achieved marked decreases in all parameters except lactate lactate blood lactate and glucose on high-intensity exercise and on moderate-intensity aerobic exercise with a marked increase in the lactate and glucose transporter-specificity measurements.
The rates of reduced lactate and glucose in the mice that had started the exercise group on high-intensity aerobic exercise remained significantly improved one month after the exercise intervention whereas lactate and glucose changed significantly in the mice that had started on high and moderate-intensity aerobic exercise but did not significantly change after sitting on either high or moderate intensities for one month.
The results from our preliminary study which was carried out in mice at one dose of 60 minutes of intense aerobic exercise five days a week were promising after testing a very small dose that was quite ineffective in preventing the onset and the progression of cardiomyopathy said the studys principal investigator Gennady Donaghuey Ph. D. of the CardioLab Molecular Imaging Center at the University of California Irvine. So this study suggests that moderate-intensity aerobic exercise training is associated with a favorable effect on cardiomyopathy based on the concurrent reduction in Treg cell activation including activation of VGF PVF neurons which are known to be involved in tract-blood flow regulation. It gives a very good indication that this treatment is potentially useful in preventing the induction of pathological blood flow deleterious changes in the heart.