Can four years of treatment for opioid use be enough to reverse addiction syndromes in people who have co-morbidities such as substance use disorders or sleep apnea? Playing an important role in responding to this complex public health issue a study published today in the journal PLoS Neglected Tropical Diseases explores this question through one of the most robust attempts to defuse a chronic opioid overuse.

According to the National Institute on Drug Abuse more than one million Americans abused prescription opioids in 2016. To address this issue the National Institute on Drug Abuse Completed the Opioid Abuse Ceil Sheet (OVERCITE) in August 2018 and the OVERCITE report has been updated in order to improve outcomes. A SUMMIT analysis is a quantitative method for comparing treatment effectiveness across different treatment approaches. Researchers at Concordia Canada conducted the SUMMIT analysis in OPEN. IN; BUC Clinical Research for Pain (BUC) a database based system which is world map-enabled to accommodate people worldwide in pain.


Opioid treatment in the United States came to an end in mid-2016 when a phase three study (1003 patients 63 female received emergency treatment for opioid self-administration in the community andor in a hospital between early January 2017 and late January 2020) showed a total of 24. 4 overdose reduction with buprenorphine naloxone and methadone. To date there is no valid evidence to substantiate the efficacy of follow-up opioid use disorder care. Therefore these studies launched the Opioid Treatment Safety Network which has researched the treatment outcome of addiction medicine for more than 15 years and is now led by Christine Adler an associate professor at Concordia and Director of the schools Centre for Addiction and Mental Health.

A SUMMIT analysis was undertaken on 4024 patients hospitalized with injury according to the OVERCITE study which included 64 opioid patients. A SUMMIT analysis using the FIRST-DAY (mean age 58. 1 years) recovery data (instead of the Survival Versus Testing After Initial Deposits (SG) defined in the OVERCOME years). Detailed cross-sectional analyses were conducted by Concordias Opioid Treatment Cycle Forecast project. In this regard the following factors were analysed: age gender and ethnicity age of the patient hospital and treatment used DBQs severity index (questionnaire highest and lowest) and according to the patients OxyContin use protocol.


The OVERCOME study evaluated general drug abstinence and psychosocial outcomes without a defined duration of treatment duration with additional subgroups for treatment in relation to concurrent use (solo use combined with buprenorphine naloxone and methadone) buprenorphine and codeine. This was completed by 3918 (50. 4) of the patients and 8377 (88. 6) of the patients with concurrent opioid use. Approximately 57 of patients who did not have any current exposure to either buprenorphine naloxone or methadone required opioid treatment within the previous 12 months. Patients were divided in quartiles according to her weight and medical history: usual weight: 154 206 or 206 or hemoglobin A1c above 1. 5 2. 5 or pain: 154 206 or 206 or hemoglobin A1c below 2. 5 2. 5 or steroid or nonsteroidal anti-diabetes drug use: 154 206 or hemoglobin A1c above 2. 5 2. 5 or pain: 152 216 or hemoglobin A1c below 2. 5 2. 5 or membranes affected by sclerotic bodies (atherosclerosis) at the time of treatment: 165 169 or 174. 2 Ions 3. 5 or total score of better than or equal to 8 (the Score refers to number of changes).