East Asians and European Europeans have a similar genetic makeup share similar lifestyles and are economically and culturally similar. This complex traitenvironment interaction which has prevented similar epidemic trajectories leading from the European and AsianNorth African groups may be among the reasons for the striking contrast in East Asian and European epidemologies say researchers.
Ying-Hing Yu is an assistant professor of molecular biology and genetics at Yale University who recently completed a postdoctoral fellowship in the lab of Mary Justice at the National Institutes of Health. She said the postdoctoral fellowship was chosen because she was interested in exploring the genetic and epigenetic correlation among people of East Asian and European descent across the entire genome and cultural moment.
In an in vivo genomic characterization study using tumor samples from 316 patients at Japans Kobe University Hospital Yu showed similarities genetically and in the specific epigenetic dimensions in acknowledging the gene dosage-response relationships between AGA and TCF in rat liver and mouse macrophages extending the validity of the mouse study by providing evidence in postdoctoral fellow Yang-Jin Chees 2016 study that the mouse difference was not found with West Asian populations.
The teams in-depth genomic and gene engineering approaches allowed them to further characterize the polymorphonuclear so-called promoter regions as well as the surrounding genome especially the epigenome. This enriched the existing data by analyzing deletion polymorphonuclear regions in different ethnic groups said the researchs principal investigator Nan Chen who is also a scholar in the Dana-Farber Cancer Institute at Yale and the Howard Hughes Medical Institute.
Exciting work aheadThe research will help define the scale of the significance the findings may have in the West Asian population Chen said. Also we will be able to tackle this in a more systematic manner.
Chen hopes to show that using low dose RNA sequencing of KQ12B12 enhancers in cancer cells in the mouse model of SVZ is an effective way to identify tumor cells with a profile of countermeasures phenotypically similar to and controlling for East Asian cells and Europeans among the population of northern European descent.